Liesbeth Reneman
Neurotoxicity and brain imaging
Focus of research:
The neurotoxicity and brain imaging group aims at unravelling the effects of drugs (of abuse) on the brain using a multidisciplinary approach and state-of-the-art neuroimaging techniques.
AMC themes: Neurological & Psychiatric Disorders
Departments: Radiology
Researchers:
The role of the serotonergic system in the development and treatment of cocaine dependence
Validating non-invasive imaging of the serotonergic and dopaminergic system and adult neurogenesis with MRI
effects of psychotropic drugs on the developing brain (ePOD)
effects of psychotropic drugs on the developing brain (ePOD)
Validation of pharmacological MR imaging in awake rodents
Effects of Methylphenidate on the Developing Brain
Neuroimaging of cognitive decline in cancer patients and cancer survivors
CONNECT
Structural, biochemical and functional indices of chemotherapy-induced cognitive deficits in breast cancer patients.
Key publications
Klomp A, Tremoleda JL, Wylezinska M, Nederveen AJ, Feenstra M, Gsell W, Reneman L, Lasting effects of chronic fluoxetine treatment on the late developing rat brain: age-dependent changes in the serotonergic neurotransmitter system assessed by pharmacological MRI. NEUROIMAGE 2012;59 (1):218-226
de Ruiter MB, Reneman L, Boogerd W, Veltman DJ, Caan M, Douaud G, Lavini C, Linn SC, Boven E, van Dam FSAM, Schagen SB, Late effects of high-dose adjuvant chemotherapy on white and gray matter in breast cancer survivors: Converging results from multimodal magnetic resonance imaging. HUM BRAIN MAPP 2012;ahead of print
Homberg JR, Olivier JDA, Blom T, Arentsen T, van Brunschot C, Schipper P, Korte-Bouws G, van Luijtelaar G, Reneman L, Fluoxetine Exerts Age-Dependent Effects on Behavior and Amygdala Neuroplasticity in the Rat. PLOS ONE 2011;6 (1):e16646
Reneman L, Lavalaye J, Schmand B, de Wolff FA, van den Brink W, den Heeten GJ, Booij J, Cortical serotonin transporter density and verbal memory in individuals who stopped using 3,4-methylenedioxymethamphetamine (MDMA or “ecstasy”): preliminary findings. ARCH GEN PSYCHIAT 2001;58 (10):901-906
Reneman L, Booij J, de Bruin K, Reitsma JB, de Wolff FA, Gunning WB, den Heeten GJ, van den Brink W, Effects of dose, sex, and long-term abstention from use on toxic effects of MDMA (ecstasy) on brain serotonin neurons. LANCET 2001;358 (9296):1864-1869