Translational Neuroradiology group
Focus of Research:
Application of non-invasive molecular neuroimaging techniques to advance Translational Neuroradiology in the broadest sense of the word (translations from structure to function, from invasive-to non-invasive, from animal to human, from group to individual and from adults to children). This unique and innovative line of research provides insight into the risks of benefit and harm (evidence based medicine) of psychotropic drugs and medicines on the brain (in development) and its application in personalized medicine.
AMC themes: Neurological & Psychiatric Disorders
Validating non-invasive imaging of the serotonergic and dopaminergic system and adult neurogenesis with MRI
“Long-lasting effects of psychotropic drugs during human brain development”
Neuroimaging of cognitive decline in cancer patients and cancer survivors
Structural, biochemical and functional indices of chemotherapy-induced cognitive deficits in breast cancer patients.
Bottelier MA, Schouw MLJ, Klomp A, Tamminga HGH, Schrantee AGM, Bouziane C, de Ruiter MB, Boer F, Ruhé HG , Denys D, Rijsman R, Lindauer RJL, Reitsma HB, Geurts HM, Reneman L, The effects of Psychotropic drugs On Developing brain (ePOD) study: methods and design. BMC PSYCHIATRY 2014;14 (1):48
van der Marel K, Klomp A, Meerhoff GF, Schipper P, Lucassen PJ, Homberg JR, Dijkhuizen RM, Reneman L, Long-term oral methylphenidate treatment in adolescent and adult rats: differential effects on brain morphology and function. NEUROPSYCHOPHARMACOL 2014;39 (2):263-273
Schouw MLJ, Kaag AM, Caan MWA, Heijtel DFR, Majoie CBLM, Nederveen AJ, Booij J, Reneman L, Mapping the hemodynamic response in human subjects to a dopaminergic challenge with dextroamphetamine using ASL-based pharmacological MRI. NEUROIMAGE 2013;72:1-9
Klomp A, Tremoleda JL, Wylezinska M, Nederveen AJ, Feenstra M, Gsell W, Reneman L, Lasting effects of chronic fluoxetine treatment on the late developing rat brain: age-dependent changes in the serotonergic neurotransmitter system assessed by pharmacological MRI. NEUROIMAGE 2012;59 (1):218-226
Reneman L, Booij J, de Bruin K, Reitsma JB, de Wolff FA, Gunning WB, den Heeten GJ, van den Brink W, Effects of dose, sex, and long-term abstention from use on toxic effects of MDMA (ecstasy) on brain serotonin neurons. LANCET 2001;358 (9296):1864-1869