Guido van Wingen


Cognitive and affective neuroscience

Focus of research

The general aim of my research is to understand the neural mechanisms underlying the development and treatment of psychiatric disorders. I therefore investigate how biological and psychological factors that are associated with psychiatric vulnerability affect the brain, as well as how successful treatment normalizes brain function and structure. To address these questions, I combine genetics, stress manipulations and various treatment approaches with noninvasive neuroimaging techniques such as functional MRI, structural MRI, DTI, and MR spectroscopy. My current research focuses on the neurobiological mechanisms underlying fear learning, identifying common and specific neural abnormalities across psychiatric disorders, and detecting neuroimaging biomarkers that predict treatment response.

AMC themes: Neurological & Psychiatric Disorders
Departments: Adult Psychiatry


Anouk van der Straten

“Predicting treatment outcome in obsessive-compulsive disorder using neuroimaging biomarkers”

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Arjan Schröder

Misophonia:an imaging study on the neurobiology and the efficacy of cognitive behavioural therapy

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Bart de Kwaasteniet

Neuroimaging of Deep Brain Stimulation in treatment-refractory patients with major depressive disorder

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Dominique Scheepens


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Judy Luigjes

Deep Brain Stimulation in Chronic Treatment refractory Drug Dependence: A Pilot Study

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Luka Liebrand

“Optimizing DBS in psychiatric patients: targeting of specific white matter bundles?”

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Nina Levar

The Impact of Individual GABA variability on the Amygdala and Fear Learning

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Paul Zhutovsky

“Discovering neuroimaging biomarkers for the prediction of treatment outcome in PTSD.”

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Rajat Thomas

“Predicting treatment outcomes for psychiatric disorders”

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Key publications

van Waarde JA, Scholte HS, van Oudheusden LJB, Verwey B, Denys D, van Wingen GA, A functional MRI marker may predict the outcome of electroconvulsive therapy in severe and treatment-resistant depression. MOL PSYCHIATR 2014;ahead of print

Kroes MCW, Tendolkar I, van Wingen GA, van Waarde JA, Strange BA, Fernández G, An electroconvulsive therapy procedure impairs reconsolidation of episodic memories in humans. NAT NEUROSCI 2014;17 (2):204-206

Figee M, Luigjes J, Smolders R, Valencia-Alfonso CE, van Wingen G, de Kwaasteniet B, Mantione M, Ooms P, de Koning P, Vulink N, Levar N, Droge L, van den Munckhof P, Schuurman PR, Nederveen A, van den Brink W, Mazaheri A, Vink M, Denys D, Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder. NAT NEUROSCI 2013;16 (4):386-387

de Kwaasteniet B, Ruhe E , Caan M, Rive M , Olabarriaga S, Groefsema M, Heesink L, van Wingen G, Denys D, Relation Between Structural and Functional Connectivity in Major Depressive Disorder. BIOL PSYCHIAT 2013;74 (1):40-47

van Wingen GA, Geuze E, Caan MWA, Kozicz T, Olabarriaga SD, Denys D, Vermetten E, Fernández G, Persistent and reversible consequences of combat stress on the mesofrontal circuit and cognition. P NATL ACAD SCI USA 2012;109 (38):15508-15513

van Wingen GA, Geuze E, Vermetten E, Fernández G, Perceived threat predicts the neural sequelae of combat stress. MOL PSYCHIATR 2011;16 (6):664-671


List of Publications

In the press (selection)





  • NPO De kennis van nu – Het bange brein


    Academic Medical Center, University of Amsterdam
    Department of Psychiatry, room PA3.128
    Meibergdreef 5
    1105 AZ Amsterdam
    The Netherlands

    Postal address:
    P.O. BOX 22660
    1100 DD Amsterdam
    The Netherlands

    Phone + 31 20 89 13523
    E-mail: (Enable Javascript to see the email address)